Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | in castrated male mice, DCC activity decreases in all parts of the small intestine, reaching values similar to those in females | Mus musculus | |
testosterone propionate | repetitive treatment of female mice with testosterone propionate for 2 weeks elicits a marked decrease in renal DCC activity | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Na+ | inverse correlation between DDC activity and sodium reabsorption in the kidney, confirming the hypothesis that dopamine inhibits sodium absorption | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
54000 | - |
predicted from amino acid sequence and determined by Western Blot analysis | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-hydroxytryptophan | Mus musculus | - |
5-hydroxytryptamine + CO2 | - |
? | |
L-Dopa | Mus musculus | - |
dopamine + CO2 | - |
? | |
additional information | Mus musculus | DDC is involved in the synthesis of dopamine, serotonin and acts as an androgen receptor co-regulator protein | ? | - |
? | |
additional information | Mus musculus | the key step in the formation of the aromatic amines dopamine, epinephrine and norepinephrine is catalyzed by a single enzyme | ? | - |
? | |
phenylalanine | Mus musculus | - |
phenylethylamine + CO2 | - |
? | |
Tryptophan | Mus musculus | - |
Tryptamine + CO2 | - |
? | |
tyrosine | Mus musculus | - |
tyramine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
immature and adult Swiss CD1 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Mus musculus | - |
brain | - |
Mus musculus | - |
colon | - |
Mus musculus | - |
duodenum | sexual dimorphism | Mus musculus | - |
heart | - |
Mus musculus | - |
ileum | sexual dimorphism | Mus musculus | - |
jejunum | sexual dimorphism | Mus musculus | - |
kidney | sexual dimorphism | Mus musculus | - |
liver | - |
Mus musculus | - |
ovary | - |
Mus musculus | - |
pancreas | - |
Mus musculus | - |
prostate | - |
Mus musculus | - |
skeletal muscle | - |
Mus musculus | - |
testis | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
2076 nmol CO2/h/g wet female adrenal gland tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
21 nmol CO2/h/g wet female skeletal muscle tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
21 nmol CO2/h/g wet male testis tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
2174 nmol CO2/h/g wet male small intestine tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
2322 nmol CO2/h/g wet male adrenal gland tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
27 nmol CO2/h/g wet male skeletal muscle tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
310 nmol CO2/h/g wet male heart tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
3200 nmol CO2/h/g wet male liver tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
3247 nmol CO2/h/g wet female kidney tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
34 nmol CO2/h/g wet female ovary tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
3410 nmol CO2/h/g wet female liver tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
384 nmol CO2/h/g wet female small intestine tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
42 nmol CO2/h/g wet male prostate tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
457 nmol CO2/h/g wet male pancreas tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
476 nmol CO2/h/g wet female heart tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
533 nmol CO2/h/g wet female pancreas tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
636 nmol CO2/h/g wet male kidney tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
798 nmol CO2/h/g wet male brain, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
853 nmol CO2/h/g wet female brain tissue, 0.1 mM pyridoxal 5'-phosphate, 0.1 mM EDTA, 2 mM dithiothreitol, 1.3 mM L-dopa, 0.03 mM dopa, DL-3,4-alanine | Mus musculus |
additional information | - |
estrogen ablation or treatment with estradiol does not affect DDC activity | Mus musculus |
additional information | - |
in kidney, DNA and protein levels of DDC are remarkably higher in females than in males (sexual dimorphism) | Mus musculus |
additional information | - |
in the small intestine, male mice display higher levels of activity than females (sexual dimorphism) | Mus musculus |
additional information | - |
sexual dimorphism of DCC in kidney has physiological relevance in sodium homeostasis | Mus musculus |
additional information | - |
treatment of female mice with testosterone propionate elicits a robust increase in DCC activity in duodenum and jejunum, which is weaker in the ileum | Mus musculus |
additional information | - |
treatment of females with testosterone propionate for short periods of time (24 and 48 h) does not significantly affect renal DCC activity, although levels of mRNA produces a marked decrease in the kidney | Mus musculus |
additional information | - |
treatment of males with the antiandrogen flutamide for short periods of time (24 and 48 h) does not significantly affect renal DCC activity, although levels of mRNA produces a marked increase in the kidney | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-hydroxytryptophan | - |
Mus musculus | 5-hydroxytryptamine + CO2 | - |
? | |
L-Dopa | - |
Mus musculus | dopamine + CO2 | - |
? | |
additional information | DDC is involved in the synthesis of dopamine, serotonin and acts as an androgen receptor co-regulator protein | Mus musculus | ? | - |
? | |
additional information | the key step in the formation of the aromatic amines dopamine, epinephrine and norepinephrine is catalyzed by a single enzyme | Mus musculus | ? | - |
? | |
phenylalanine | - |
Mus musculus | phenylethylamine + CO2 | - |
? | |
Tryptophan | - |
Mus musculus | Tryptamine + CO2 | - |
? | |
tyrosine | - |
Mus musculus | tyramine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3,4-Dihydroxyphenylalanine decarboxylase | - |
Mus musculus |
AADC | - |
Mus musculus |
Aromatic L-amino acid decarboxylase | - |
Mus musculus |
DDC | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Mus musculus |